Circulating A-FABP level predicts the development of CVD after adjustment for traditional risk factors in a community-based cohort. MRIs were centrally read by neuroradiologists in a standardized, blinded manner. Conclusions Journal of the American Heart Association Impact Factor, IF, number of article, detailed information and journal factor. ).Metabolic syndrome (MetS) enhances salt sensitivity of blood pressure and is an important risk factor for cardiovascular disease. To examine the therapeutic efficacy of ADRC implantation in vivo, we established a new mouse model of tail lymphedema. Clinical Trial Registration [2][2] For young adults aged 20 to 34Risk of Ischemic Cerebrovascular and Coronary Events in Adult Users of Anticonvulsant Medications in Routine Care SettingsOlder-generation anticonvulsants that highly induce cytochrome P450 enzyme system activity produce metabolic abnormalities that may increase cardiovascular risk.
We investigated the association between plasma phospholipid omega-3 polyunsaturated fatty acids (PUFAs), objective biomarkers of exposure, and subclinical brain abnormalities on MRI. © 2014 The Authors. Identifying the differences in the mechanisms or repair of these 2 types of injuries could help to develop novel regenerative therapies relevant to human patients. Methods and Results We generated and validated a model for transfemoral access site complications during PCI. Data from 7690 men and nonpregnant women who were aged 40 to 79 years, who were free of self-reported heart disease and stroke, and who participated in a National Health and Nutrition Examination Survey from 2005 to 2012 were analyzed. Immunofluorescence analysis revealed significantly higher cTnI content in hypertrophic cardiomyocytes. These data indicate that α1-AR signaling originates in the nucleus. Nevertheless, patients with symptomatic drug refractory long-standing atrial fibrillation present a particular challenge for treatment with catheter ablation techniques. In particular, we discuss the sirtuin-1 system, the p66Shc pathway, telomeres, and their interrelationships with endothelial damage and repair.The paper in this edition of JAHA by Iwami, et al.
Outcomes included 1-year risk of major adverse cardiac events and bleeding according to Global Utilization of Strategies To Open Occluded Arteries (GUSTO) and Bleeding Academic Research Consortium (BARC) definitions. In the community-based Cardiovascular Health Study, 3660 participants aged ≥65 underwent brain MRI in 1992-1994, and 2313 were rescanned 5 years later.
Large hematomas (>30 mL) had higher Ktrans values than small hematomas (P<0.005). Methods and Results In vivo vascular macrophage uptake and ablation were then investigated in carotid-ligated FVB mice (n=33) after induction of hyperlipidemia and diabetes. Nevertheless, patients with symptomatic drug refractory long-standing atrial fibrillation present a particular challenge for treatment with catheter ablation techniques. ST-segment elevation myocardial infarction (STEMI) patients (n=140) were monitored for total creatine kinase (CK) and cardiac troponin I (cTnI) over 72 hours postinfarction and were examined by cardiac magnetic resonance (CMR) at 1 week and 6 months postinfarction. Receiver operating characteristic (ROC) curve analysis was performed to study the discriminatory capacity of the area under the curve (AUC) of cTnI and total CK in predicting LV dysfunction. The Global Registry of Acute Coronary Events mortality risk score was not associated with the risk of rehospitalization for ACS or revascularization. In addition, dietary salt restriction attenuated the increase in visceral adipose tissue inflammation and the decrease in insulin signaling apparent in DS/obese rats without reducing body weight or visceral adipocyte size. Adipose tissue inflammation and perturbation of adipokine secretion may contribute to the pathogenesis of CVD. We sought to develop a prediction model for access site complications in patients undergoing PCI with femoral arteriotomy, and assess whether transradial access was selectively used in patients at high risk for complications. Participants with recognized transient ischemic attacks or stroke were excluded. The evolution of epicardial ablation tools created the ability to access portions of the left atrium either through mini-thoracotomies or using thoracoscopic tools. © 2014 The Authors. BBB leakage in the brain tissue immediately bordering the hematoma can be measured and quantified by DCE MRI in human ICH. The age-adjusted percentages of predicted cardiovascular risk ≥20% for the 6 intervals of sleep duration were 14.5%, 11.9%, 11.0%, 11.4%, 11.8%, and 16.3% (PWald chi-square=0.022).
Dietary salt restriction attenuated all of these changes in DS/obese rats. Dietary salt restriction not only prevents hypertension and cardiac injury but also ameliorates insulin resistance, without reducing obesity, in this model of metabolic syndrome. Patients with EF ≤35% at discharge continued to be at long-term risk for ICD therapy compared with those with EF >35% who were at increased risk predominantly in the first 8 months.
We investigated the association between plasma phospholipid omega-3 polyunsaturated fatty acids (PUFAs), objective biomarkers of exposure, and subclinical brain abnormalities on MRI. © 2014 The Authors. Identifying the differences in the mechanisms or repair of these 2 types of injuries could help to develop novel regenerative therapies relevant to human patients. Methods and Results We generated and validated a model for transfemoral access site complications during PCI. Data from 7690 men and nonpregnant women who were aged 40 to 79 years, who were free of self-reported heart disease and stroke, and who participated in a National Health and Nutrition Examination Survey from 2005 to 2012 were analyzed. Immunofluorescence analysis revealed significantly higher cTnI content in hypertrophic cardiomyocytes. These data indicate that α1-AR signaling originates in the nucleus. Nevertheless, patients with symptomatic drug refractory long-standing atrial fibrillation present a particular challenge for treatment with catheter ablation techniques. In particular, we discuss the sirtuin-1 system, the p66Shc pathway, telomeres, and their interrelationships with endothelial damage and repair.The paper in this edition of JAHA by Iwami, et al.
Outcomes included 1-year risk of major adverse cardiac events and bleeding according to Global Utilization of Strategies To Open Occluded Arteries (GUSTO) and Bleeding Academic Research Consortium (BARC) definitions. In the community-based Cardiovascular Health Study, 3660 participants aged ≥65 underwent brain MRI in 1992-1994, and 2313 were rescanned 5 years later.
Large hematomas (>30 mL) had higher Ktrans values than small hematomas (P<0.005). Methods and Results In vivo vascular macrophage uptake and ablation were then investigated in carotid-ligated FVB mice (n=33) after induction of hyperlipidemia and diabetes. Nevertheless, patients with symptomatic drug refractory long-standing atrial fibrillation present a particular challenge for treatment with catheter ablation techniques. ST-segment elevation myocardial infarction (STEMI) patients (n=140) were monitored for total creatine kinase (CK) and cardiac troponin I (cTnI) over 72 hours postinfarction and were examined by cardiac magnetic resonance (CMR) at 1 week and 6 months postinfarction. Receiver operating characteristic (ROC) curve analysis was performed to study the discriminatory capacity of the area under the curve (AUC) of cTnI and total CK in predicting LV dysfunction. The Global Registry of Acute Coronary Events mortality risk score was not associated with the risk of rehospitalization for ACS or revascularization. In addition, dietary salt restriction attenuated the increase in visceral adipose tissue inflammation and the decrease in insulin signaling apparent in DS/obese rats without reducing body weight or visceral adipocyte size. Adipose tissue inflammation and perturbation of adipokine secretion may contribute to the pathogenesis of CVD. We sought to develop a prediction model for access site complications in patients undergoing PCI with femoral arteriotomy, and assess whether transradial access was selectively used in patients at high risk for complications. Participants with recognized transient ischemic attacks or stroke were excluded. The evolution of epicardial ablation tools created the ability to access portions of the left atrium either through mini-thoracotomies or using thoracoscopic tools. © 2014 The Authors. BBB leakage in the brain tissue immediately bordering the hematoma can be measured and quantified by DCE MRI in human ICH. The age-adjusted percentages of predicted cardiovascular risk ≥20% for the 6 intervals of sleep duration were 14.5%, 11.9%, 11.0%, 11.4%, 11.8%, and 16.3% (PWald chi-square=0.022).
Dietary salt restriction attenuated all of these changes in DS/obese rats. Dietary salt restriction not only prevents hypertension and cardiac injury but also ameliorates insulin resistance, without reducing obesity, in this model of metabolic syndrome. Patients with EF ≤35% at discharge continued to be at long-term risk for ICD therapy compared with those with EF >35% who were at increased risk predominantly in the first 8 months.