In the present study, we investigated the incidence of R1 and its impact on survival after oncologic pancreatic resections using a standardized pathologic routine protocol.We performed 265 pancreatic resections from September 2003 to September 2010. DOI: 10.1002/bjs.5397 Corpus ID: 27342005. In the present study, we investigated the incidence of R1 and its impact on survival after oncologic pancreatic resections using a standardized pathologic routine protocol.We performed 265 pancreatic resections from September 2003 to September 2010. By continuing you agree to the Copyright © 2020 Elsevier B.V. or its licensors or contributors. Ramkiran Cherukuru, Sanjay Govil, Mukul Vij, Mohamed Rela, Vein resection in patients with adenocarcinoma of the head of pancreas adherent to the portomesenteric venous axis is beneficial despite a high rate of R1 resection, Annals of Hepato-Biliary-Pancreatic Surgery, 10.14701/ahbps.2018.22.3.261, 22, 3, (261), (2018). From 2001 to 2015, 100 consecutive patients with IPDC who underwent pancreatic resection in our hospital were enrolled. Follow-up was performed after a median of 17 months (range, 1–85) postoperatively. In pancreatic adenocarcinoma, the rate of R1 was 51% (48/94). Cancer-related death rate in R0 and R1-resected patients was 60% and 83% (Our 51% rate of R1 resections in ductal pancreatic carcinoma indicates a high quality standard of pathologic evaluation.
The vast majority of R1 margins are located at the retroperitoneal dissection surface. Despite recent advances in surgical treatment and adjuvant therapy, the survival rates By continuing you agree to the Copyright © 2020 Elsevier B.V. or its licensors or contributors. R1 resection involved most frequently the circumferential margin in 86% (48/125) of the total group and in 92% (44/48) in pancreatic cancer. Cancer-related death rate in R0 and R1-resected patients was 60% and 83% (Our 51% rate of R1 resections in ductal pancreatic carcinoma indicates a high quality standard of pathologic evaluation. The quality of a histopathologic workup after oncologic resection of pancreatic malignancies has changed the central role of surgery substantially for radical tumor clearance over the past years. Although general guidelines for the processing of pancreatic specimens have been established, there is currently no widely accepted standardized protocol for pathological examination, especially with respect to resection margins. Traditionally, R0 represents no cancer at the margins, while R1 represents microscopic disease at the margin, and R2 is representative of gross disease at the margins (seen by naked eye). The development of standardized protocols for pathologic workup increased the rate of R1 resections from around 20% up to 80%. The CRM of pancreatic resection specimens consists of the anterior, posterior and, in the case of PD, medial pancreatic surface. In pancreatic adenocarcinoma, the rate of R1 was 51% (48/94). R1 resection involved most frequently the circumferential margin in 86% (48/125) of the total group and in 92% (44/48) in pancreatic cancer. Among 128 patients with malignant neoplasms, histology revealed ductal pancreatic adenocarcinoma in 97, ampullary cancer in 10, and distal bile duct cancer in 21 patients. The development of standardized protocols for pathologic workup increased the rate of R1 resections from around 20% up to 80%. Methods.
Resected specimens were analyzed according to this improved standardized pathology protocol introduced in 2000. Introduction Pancreatic ductal adenoacarcinoma (PDAC) is one of the most aggressive tumors with an extremely poor prognosis.
Standardization of histopathologic analysis has a clinically relevant impact on survival after oncologic resection of pancreatic cancer and can be achieved by less extensive protocols.We use cookies to help provide and enhance our service and tailor content and ads. The quality of a histopathologic workup after oncologic resection of pancreatic malignancies has changed the central role of surgery substantially for radical tumor clearance over the past years. In the overall series, 56 (44%) were classified R1 resections and 68 (43%) R0 resections, 3 patients with R2 resections were excluded, leaving 125 patients for analysis.
The vast majority of R1 margins are located at the retroperitoneal dissection surface. Despite recent advances in surgical treatment and adjuvant therapy, the survival rates By continuing you agree to the Copyright © 2020 Elsevier B.V. or its licensors or contributors. R1 resection involved most frequently the circumferential margin in 86% (48/125) of the total group and in 92% (44/48) in pancreatic cancer. Cancer-related death rate in R0 and R1-resected patients was 60% and 83% (Our 51% rate of R1 resections in ductal pancreatic carcinoma indicates a high quality standard of pathologic evaluation. The quality of a histopathologic workup after oncologic resection of pancreatic malignancies has changed the central role of surgery substantially for radical tumor clearance over the past years. Although general guidelines for the processing of pancreatic specimens have been established, there is currently no widely accepted standardized protocol for pathological examination, especially with respect to resection margins. Traditionally, R0 represents no cancer at the margins, while R1 represents microscopic disease at the margin, and R2 is representative of gross disease at the margins (seen by naked eye). The development of standardized protocols for pathologic workup increased the rate of R1 resections from around 20% up to 80%. The CRM of pancreatic resection specimens consists of the anterior, posterior and, in the case of PD, medial pancreatic surface. In pancreatic adenocarcinoma, the rate of R1 was 51% (48/94). R1 resection involved most frequently the circumferential margin in 86% (48/125) of the total group and in 92% (44/48) in pancreatic cancer. Among 128 patients with malignant neoplasms, histology revealed ductal pancreatic adenocarcinoma in 97, ampullary cancer in 10, and distal bile duct cancer in 21 patients. The development of standardized protocols for pathologic workup increased the rate of R1 resections from around 20% up to 80%. Methods.
Resected specimens were analyzed according to this improved standardized pathology protocol introduced in 2000. Introduction Pancreatic ductal adenoacarcinoma (PDAC) is one of the most aggressive tumors with an extremely poor prognosis.
Standardization of histopathologic analysis has a clinically relevant impact on survival after oncologic resection of pancreatic cancer and can be achieved by less extensive protocols.We use cookies to help provide and enhance our service and tailor content and ads. The quality of a histopathologic workup after oncologic resection of pancreatic malignancies has changed the central role of surgery substantially for radical tumor clearance over the past years. In the overall series, 56 (44%) were classified R1 resections and 68 (43%) R0 resections, 3 patients with R2 resections were excluded, leaving 125 patients for analysis.